Enhanced Liver Fibrosis | Modern Wellness Diagnostic Services Blog
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ELF Profile

Sep 10, 2019

ELF stands for Enhanced Liver Fibrosis. The ELF™ Blood Test is a routine blood test used to assess the severity of liver fibrosis. Liver fibrosis is the scarring process that represents the liver’s response to injury or disease. Chronic liver disease can lead to liver fibrosis, liver cancer and death. Cirrhosis and liver cancer are now among the top ten causes of death worldwide, and in many developed countries, liver disease is now one of the top 5 causes of death in middle age. There are three main causes of fibrosis:

  • Fatty liver disease associated with obesity
  • Viral hepatitis B and C
  • Type 2 Diabetes/Metabolic Syndrome
  • Alcohol Abuse

ELF Profile

The ELF Blood Test combines three serum biomarkers, which, when correlated, are able to identify a quantifiable level of liver fibrosis. The extent of liver damage is determined by a score based on the measurement of three substances:

  • Hyaluronic acid (HA)
  • Procollagen III amino terminal peptide (PIIINP)
  • Tissue inhibitor of metalloproteinase 1 (TIMP-1)

ELF Profile

The algorithm of these three markers creates an ELF Score. This ELF score has been proven to correlate to the level of fibrosis assessed by liver biopsy. The spectrum of liver disease can range from simple steatosis, to cirrhosis and may be present for many years in the absence of abnormal liver function tests – mild to moderate liver fibrosis can exist without symptoms, which in itself supports its use for early detection and assessment.

ELF Profile

This test offers the following benefits:

  • Identification of early or significant liver disease.
  • Allows for cost effective screening test and subsequent review/follow-up response to treatment
  • Minimally-invasive routine serum sample vs invasive biopsy
  • Mathematical algorithm to assess extent of liver damage

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